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Article

Structures of five mutants of toxic shock syndrome toxin-1 with reduced biological activity.

Biochemistry - 19 May 1998

Earhart C A, Mitchell D T, Murray D L, Pinheiro D M, Matsumura M, Schlievert P M, Ohlendorf D H

Abstract excerpt

The three-dimensional structures of five mutants of toxic shock syndrome toxin-1 (TSST-1) have been determined. These mutations are in the long central alpha helix and are useful in mapping portions of TSST-1 involved in superantigenicity and lethality. The T128A, H135A, Q139K, and I140T mutations appear to reduce superantigenicity by altering the properties of the T-cell receptor interaction surface. The Q136A...

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Identifiers

PMID: 9585531
DOI: 10.1021/bi9721896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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