Structures of five mutants of toxic shock syndrome toxin-1 with reduced biological activity.

doi:10.1021/bi9721896

Back to search

Article

Structures of five mutants of toxic shock syndrome toxin-1 with reduced biological activity.

Biochemistry - 19 May 1998

Earhart C A, Mitchell D T, Murray D L, Pinheiro D M, Matsumura M, Schlievert P M, Ohlendorf D H

Abstract excerpt

The three-dimensional structures of five mutants of toxic shock syndrome toxin-1 (TSST-1) have been determined. These mutations are in the long central alpha helix and are useful in mapping portions of TSST-1 involved in superantigenicity and lethality. The T128A, H135A, Q139K, and I140T mutation...

Topics

Alanine
Animals
Bacterial Toxins
Crystallography, X-Ray
Enterotoxins
Glutamine
Histidine
Humans
Lysine
Mice
Models, Molecular
Mutation
Rabbits
Staphylococcus aureus
Superantigens
Threonine

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.