Article
Glutathione-S-transferase expression in the brain: possible role in ethanol preference and longevity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2006
Björk K, Saarikoski S T, Arlinde C, Kovanen L, Osei-Hyiaman D, Ubaldi M, Reimers M, Hyytiä P, Heilig M, Sommer W H
Abstract excerpt
Identification of genes that are differentially expressed in rats bidirectionally selected for alcohol preference might reveal biological mechanisms underlying alcoholism or related phenotypes. Microarray analysis from medial prefrontal cortex (mPFC), a key brain region for drug reward, indicated increased expression of glutathione-S-transferases of the alpha (Gsta4) and mu (Gstm1-5) classes in ethanol-preferring...
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