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Article

Human alpha class glutathione S-transferases: genetic polymorphism, expression, and susceptibility to disease.

Methods in enzymology - 1 Jan 2005

Coles Brian F, Kadlubar Fred F

Abstract excerpt

The human alpha class glutathione S-transferases (GSTs) consist of 5 genes, hGSTA1-hGSTA5, and 7 pseudogenes on chromosome 6p12.1-6p12.2. hGSTA1-hGSTA4 have been well characterized as proteins, but hGSTA5 has not been detected as a gene product. hGSTA1-1 (and to a lesser extent hGSTA2-2) catalyzes the GSH-dependent detoxification of carcinogenic metabolites of environmental pollutants and tobacco smoke (e.g.,...

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PMID: 16399377
DOI: 10.1016/S0076-6879(05)01002-5

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