Article
Polymorphism of the rat liver mitochondrial aldehyde dehydrogenase cDNA.
Alcoholism, clinical and experimental research - 1 Oct 1991
Carr L G, Mellencamp R J, Crabb D W, Weiner H, Lumeng L, Li T K
Abstract excerpt
In humans, a deficiency in mitochondrial aldehyde dehydrogenase (Class 2 ALDH) activity due to a single base-pair exchange in its structural gene serves as a deterrent to excessive alcohol consumption. Differences in Class 2 ALDH isozyme patterns on isoelectric focusing gels have been observed in...
Topics
- Alcoholism
- Aldehyde Dehydrogenase
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA
- DNA Probes
- Gene Amplification
- Genotype
- Isoenzymes
- Mitochondria, Liver
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Rats
- Rats, Inbred Strains