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Article

Polymorphism of the rat liver mitochondrial aldehyde dehydrogenase cDNA.

Alcoholism, clinical and experimental research - 1 Oct 1991

Carr L G, Mellencamp R J, Crabb D W, Weiner H, Lumeng L, Li T K

Abstract excerpt

In humans, a deficiency in mitochondrial aldehyde dehydrogenase (Class 2 ALDH) activity due to a single base-pair exchange in its structural gene serves as a deterrent to excessive alcohol consumption. Differences in Class 2 ALDH isozyme patterns on isoelectric focusing gels have been observed in the selectively bred, alcohol-preferring (P) and alcohol-nonpreferring (NP) lines of rats. To determine whether the...

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Source

Identifiers

PMID: 1755504
DOI: 10.1111/j.1530-0277.1991.tb00593.x

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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