Article
Expression profiling and QTL analysis: a powerful complementary strategy in drug abuse research.
Addiction biology - 1 Mar 2005
Spence John, Liang Tiebing, Foroud Tatiana, Lo David, Carr Lucinda
Abstract excerpt
Alcoholism is a complex disease exhibiting a multifactorial mode of transmission. To simplify the genetic and phenotypic complexity of the alcoholic phenotype, alcohol-preferring (P) and -non-preferring (NP) rats were developed on the basis of alcohol preference and consumption as an animal model of alcoholism. Total gene expression analysis (TOGA) and quantitative trait loci (QTL) analysis were applied to...
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