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Article

A quantitative trait locus for alcohol consumption in selectively bred rat lines.

Alcoholism, clinical and experimental research - 1 Jun 1998

Carr L G, Foroud T, Bice P, Gobbett T, Ivashina J, Edenberg H, Lumeng L, Li T K

Abstract excerpt

Selective breeding for high and low alcohol consumption led to the establishment of alcohol-preferring (P) and alcohol-nonpreferring (NP) rat lines that differ greatly in their alcohol consumption. These lines were inbred and F2 intercross progenies were generated to detect quantitative trait loci (QTLs) influencing alcohol consumption. A QTL on chromosome 4 was identified with a maximum lod score of 8.6. This...

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PMID: 9660316

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