Inactivation of the cellular p53 gene is a common feature of Friend virus-induced erythroleukemia: relationship of inactivation to dominant transforming alleles.

doi:10.1128/mcb.10.7.3307-3313.1990

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Article

Inactivation of the cellular p53 gene is a common feature of Friend virus-induced erythroleukemia: relationship of inactivation to dominant transforming alleles.

Molecular and cellular biology - 1 Jul 1990

Munroe D G, Peacock J W, Benchimol S

Abstract excerpt

The Friend erythroleukemia virus complex contains no cell-derived oncogene. Transformation by this virus may therefore involve mutations affecting cellular gene expression. We provide evidence that inactivating mutations of the cellular p53 gene are a common feature in Friend virus-induced malignancy, consistent with an antioncogene role for p53 in this disease. We have shown that frequent rearrangements of the...

Topics

Alleles
Amino Acid Sequence
Animals
Base Sequence
Cell Transformation, Neoplastic
Cells, Cultured
Cloning, Molecular
Embryo, Mammalian
Epitopes
Friend murine leukemia virus
Gene Amplification

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Dominant

Leukemia, Erythroblastic, Acute

Leukemia, Experimental

Molecular Sequence Data

Nuclear Proteins

Oligonucleotide Probes

Oncogene Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 1694008
DOI: 10.1128/mcb.10.7.3307-3313.1990
PMCID: PMC360748

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1694008-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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