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Article

Inhibition of HERG channels by the local anaesthetic articaine.

European journal of anaesthesiology - 1 Feb 2007

Siebrands C C, Friederich P

Abstract excerpt

BACKGROUND AND OBJECTIVE: Articaine is an amide local anaesthetic widely used in dentistry. Human ether-a-go-go-related gene (HERG) potassium channels constitute potential targets involved in cardiotoxic side-effects of various pharmacological agents including amide local anaesthetics. The aim of this study was to determine the sensitivity of HERG channels to the inhibitory action of articaine and to further...

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Source

Identifiers

PMID: 16938156
DOI: 10.1017/S0265021506001311

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of HERG channels by the local anaesthetic articaine.PMID 16938156Read ↗

Local anesthetic interaction with human ether-a-go-go-related gene (HERG) channels: role of aromatic amino acids Y652 and F656.Semantic proximity Read ↗

Inhibition of the HERG K+ channel by the antifungal drug ketoconazole depends on channel gating and involves the S6 residue F656.Semantic proximity Read ↗

Blockade of the human ether-a-go-go-related gene potassium channel by ketamine.Semantic proximity Read ↗

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Inactivation gating determines drug potency: a common mechanism for drug blockade of HERG channels.Semantic proximity Read ↗

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Pharmacological corrections of the mutant hERG channels by posaconazole.Semantic proximity Read ↗

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Molecular Determinants for the High-Affinity Blockade of Human Ether-à-go-go-Related Gene K + Channel by Tolterodine.Semantic proximity Read ↗

The opioid methadone induces a local anaesthetic-like inhibition of the cardiac Na⁺ channel, Na(v)1.5.Semantic proximity Read ↗

Mechanism of action of a novel human ether-a-go-go-related gene channel activator.Semantic proximity Read ↗

Papaverine, a vasodilator, blocks the pore of the HERG channel at submicromolar concentration.Semantic proximity Read ↗

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