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Article

Mechanism of action of a novel human ether-a-go-go-related gene channel activator.

Molecular pharmacology - 1 Feb 2006

Casis Oscar, Olesen Søren-Peter, Sanguinetti Michael C

Abstract excerpt

1,3-Bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) is a newly discovered activator of human ether-a-go-go-related gene (hERG) K(+) channels. Here, we characterize the effects of this compound on cloned hERG channels heterologously expressed in Xenopus laevis oocytes. When assessed with 2-s depolarizations, NS1643 enhanced the magnitude of wild-type hERG current in a concentration- and voltage-dependent...

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Identifiers

PMID: 16284303
DOI: 10.1124/mol.105.019943

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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