Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

En2 knockout mice display neurobehavioral and neurochemical alterations relevant to autism spectrum disorder.

Brain research - 20 Oct 2006

Cheh Michelle A, Millonig James H, Roselli Lauren M, Ming Xue, Jacobsen Erin, Kamdar Silky, Wagner George C

Abstract excerpt

Autism spectrum disorder (ASD) is a prevalent and inheritable neurodevelopmental disorder. Recent human genetic studies are consistent with the homeobox transcription factor, ENGRAILED 2 (EN2), being an ASD susceptibility gene. En2 knockout mice (En2(-/-)) display subtle cerebellar neuropathological changes similar to what has been observed in the ASD brain. To investigate whether En2(-/-) mice displayed abnormal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aggression
Share to Autistic Disorder

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Brain Chemistry

Share to Learning

Share to Maze Learning

Share to Memory

Share to Motor Activity

Share to Social Behavior

Source

Identifiers

PMID: 16935268
DOI: 10.1016/j.brainres.2006.07.086

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

En2 knockout mice display neurobehavioral and neurochemical alterations relevant to autism spectrum disorder.PMID 16935268Read ↗

Developmental delays and reduced pup ultrasonic vocalizations but normal sociability in mice lacking the postsynaptic cell adhesion protein neuroligin2.Semantic proximity Read ↗

Nest building is impaired in the Ts65Dn mouse model of Down syndrome and rescued by blocking 5HT2a receptors.Semantic proximity Read ↗

Association of the homeobox transcription factor, ENGRAILED 2, 3, with autism spectrum disorder.Semantic proximity Read ↗

Comprehensive Analysis of the 16p11.2 Deletion and Null Cntnap2 Mouse Models of Autism Spectrum Disorder.Semantic proximity Read ↗

Heterogeneous association between engrailed-2 and autism in the CPEA network.Semantic proximity Read ↗

Cerebellar Purkinje cell p75 neurotrophin receptor and autistic behavior.Semantic proximity Read ↗

Neurexin dysfunction in adult neurons results in autistic-like behavior in mice.Semantic proximity Read ↗

Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism.Semantic proximity Read ↗

Uncoupling memory impairments from autism-associated behaviors in Chd2 deficient mice.Semantic proximity Read ↗

Behavioral profiles of mouse models for autism spectrum disorders.Semantic proximity Read ↗

ASTN2 in ASD and neurodevelopmental disorders.Semantic proximity Read ↗

Behavioral regression in shank3Δex4-22 mice during early adulthood corresponds to cerebellar granule cell glutamatergic synaptic changesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.