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Article

Association of the homeobox transcription factor, ENGRAILED 2, 3, with autism spectrum disorder.

Molecular psychiatry - 1 May 2004

Gharani N, Benayed R, Mancuso V, Brzustowicz L M, Millonig J H

Abstract excerpt

Mouse mutants of the homeobox transcription factor Engrailed2 (En2) and autistic individuals display similar cerebellar morphological abnormalities, which include hypoplasia and a decrease in the number of Purkinje cells. Human EN2 maps to 7q36, a chromosomal region that has demonstrated suggestive linkage to autism spectrum disorder (ASD). To investigate EN2 for evidence of association with ASD, four...

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Identifiers

PMID: 15024396
DOI: 10.1038/sj.mp.4001498

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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