Article
Comprehensive Analysis of the 16p11.2 Deletion and Null Cntnap2 Mouse Models of Autism Spectrum Disorder.
PloS one - 1 Jan 2015
Brunner Daniela, Kabitzke Patricia, He Dansha, Cox Kimberly, Thiede Lucinda, Hanania Taleen, Sabath Emily, Alexandrov Vadim, Saxe Michael, Peles Elior, Mills Alea, Spooren Will, Ghosh Anirvan, Feliciano Pamela, Benedetti Marta, Luo Clayton Alice, Biemans Barbara
Abstract excerpt
Autism spectrum disorder comprises several neurodevelopmental conditions presenting symptoms in social communication and restricted, repetitive behaviors. A major roadblock for drug development for autism is the lack of robust behavioral signatures predictive of clinical efficacy. To address this issue, we further characterized, in a uniform and rigorous way, mouse models of autism that are of interest because of...
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