Heterogeneous association between engrailed-2 and autism in the CPEA network.

doi:10.1002/ajmg.b.30585

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Article

Heterogeneous association between engrailed-2 and autism in the CPEA network.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Mar 2008

Brune Camille W, Korvatska Elena, Allen-Brady Kristina, Cook Edwin H, Dawson Geraldine, Devlin Bernie, Estes Annette, Hennelly Meghann, Hyman Susan L, McMahon William M, Munson Jeffrey, Rodier Patricia M, Schellenberg Gerard D, Stodgell Christopher J, Coon Hilary

Abstract excerpt

Autism is a neurodevelopmental disorder characterized by an early onset of abnormal social, communicative, and repetitive behavior. Engrailed-2 (EN2) was identified as an autism candidate gene because its influence on cerebellar development in mice parallels neurodevelopmental abnormalities seen in individuals with autism. Studies investigating association between markers at EN2 (chr7q36), a location associated...

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PMID: 17948868
DOI: 10.1002/ajmg.b.30585

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