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Article

SrGAP3 knockout mice display enlarged lateral ventricles and specific cilia disturbances of ependymal cells in the third ventricle.

Cell and tissue research - 1 Aug 2015

Koschützke Leif, Bertram Jonathan, Hartmann Bianca, Bartsch Dusan, Lotze Martin, von Bohlen und Halbach Oliver

Abstract excerpt

In several mouse models of mental retardation, ventricular enlargements have been observed. Mutation in the SrGAP3 gene residing on chromosome 3p25 has previously been associated with intellectual disability in humans. In addition, SrGAP3 is related to Rho-GAPs signaling pathways, which play essential roles in the development and plasticity of the nervous system. About 10 % of postnatal homozygous...

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PMID: 26104135
DOI: 10.1007/s00441-015-2224-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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