Article
Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus.
Nature neuroscience - 1 Jun 2010
Tissir Fadel, Qu Yibo, Montcouquiol Mireille, Zhou Libing, Komatsu Kouji, Shi Dongbo, Fujimori Toshihiko, Labeau Jason, Tyteca Donatienne, Courtoy Pierre, Poumay Yves, Uemura Tadashi, Goffinet Andre M
Abstract excerpt
Ependymal cells form the epithelial lining of cerebral ventricles. Their apical surface is covered by cilia that beat in a coordinated fashion to facilitate circulation of the cerebrospinal fluid (CSF). The genetic factors that govern the development and function of ependymal cilia remain poorly understood. We found that the planar cell polarity cadherins Celsr2 and Celsr3 control these processes. In...
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