Article
Msx1 disruption leads to diencephalon defects and hydrocephalus.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jul 2004
Ramos Casto, Fernández-Llebrez Pedro, Bach Antoine, Robert Benoît, Soriano Eduardo
Abstract excerpt
We have analyzed the expression of the Msx1 gene in the developing mouse brain and examined the brain phenotype in homozygotes. Msx1 is expressed in every cerebral vesicle throughout development, particularly in neuroepithelia, such as those of the fimbria and the medulla. Timing analysis suggests that Msx1(nLacZ) cells delaminate and migrate radially from these epithelia, mainly at embryonic days 14-16, while...
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