Potent inhibition of cytochrome P450IID6 (debrisoquin 4-hydroxylase) by flecainide in vitro and in vivo.

Abstract excerpt

Flecainide acetate, a class Ic antiarrhythmic agent, is eliminated to a larger extent by renal excretion and to a minor extent by the liver. In patients with impaired renal function or with elevated urinary pH, however, its elimination is dominated by hepatic metabolism. Recent evidence suggests...

Topics

• Adult
• Cytochrome P-450 CYP2D6
• Cytochrome P-450 Enzyme Inhibitors
• Debrisoquin
• Dextromethorphan
• Ethanolamines
• Flecainide
• Humans
• In Vitro Techniques
• Kinetics
• Male
• Microsomes, Liver