The influence of the sparteine/debrisoquine genetic polymorphism on the disposition of dexfenfluramine.

doi:10.1046/j.1365-2125.1996.03178.x

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Article

The influence of the sparteine/debrisoquine genetic polymorphism on the disposition of dexfenfluramine.

British journal of clinical pharmacology - 1 Apr 1996

Gross A S, Phillips A C, Rieutord A, Shenfield G M

Abstract excerpt

1. To determine whether dexfenfluramine is a substrate of cytochrome P450 2D6 (CYP2D6), its disposition has been studied in nine extensive (EM) and eight poor metabolizers (PM) of debrisoquine. 2. Following a 30 mg dose of dexfenfluramine hydrochloride, urine was collected in all subjects for 96...

Topics

Adult
Appetite Depressants
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Debrisoquin
Female
Fenfluramine
Humans
Isoenzymes
Male
Mixed Function Oxygenases
Phenotype
Polymorphism, Genetic

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