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Article

Effects of CYP2D6 genotypes on age-related change of flecainide metabolism: involvement of CYP1A2-mediated metabolism.

British journal of clinical pharmacology - 1 Jul 2009

Doki Kosuke, Homma Masato, Kuga Keisuke, Aonuma Kazutaka, Kohda Yukinao

Abstract excerpt

AIMS: The aim of this study was to clarify the effects of CYP2D6 genotype on age-related change in flecainide metabolism in patients with supraventricular tachyarrhythmias. An in vitro study using microsomes was performed to identify other CYPs responsible for age-related change in flecainide metabolism. METHODS: The study population comprised 111 genotyped patients: CYP2D6-homozygous extensive metabolizers...

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Source

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Identifiers

PMID: 19660006
DOI: 10.1111/j.1365-2125.2009.03435.x
PMCID: PMC2732943

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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