Article
SHBG gene promoter polymorphisms in men are associated with serum sex hormone-binding globulin, androgen and androgen metabolite levels, and hip bone mineral density.
The Journal of clinical endocrinology and metabolism - 1 Dec 2006
Eriksson A L, Lorentzon M, Mellström D, Vandenput L, Swanson C, Andersson N, Hammond G L, Jakobsson J, Rane A, Orwoll E S, Ljunggren O, Johnell O, Labrie F, Windahl S H, Ohlsson C
Abstract excerpt
CONTEXT: SHBG regulates free sex steroid levels, which in turn regulate skeletal homeostasis. Twin studies have demonstrated that genetic factors largely account for interindividual variation in SHBG levels. Glucuronidated androgen metabolites have been proposed as markers of androgenic activity. OBJECTIVE: Our objective was to investigate whether polymorphisms in the SHBG gene promoter [(TAAAA)(n) microsatellite...
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