Article
Identification of common variants in the SHBG gene affecting sex hormone-binding globulin levels and breast cancer risk in postmenopausal women.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2008
Thompson Deborah J, Healey Catherine S, Baynes Caroline, Kalmyrzaev Bolot, Ahmed Shahana, Dowsett Mitch, Folkerd Elizabeth, Luben Robert N, Cox David, Ballinger Dennis, Pharoah Paul D P, Ponder Bruce A J, Dunning Alison M, Easton Douglas F
Abstract excerpt
BACKGROUND: Circulating levels of sex hormone-binding globulin (SHBG) are inversely associated with breast cancer risk in postmenopausal women. Three polymorphisms within the SHBG gene have been reported to affect SHBG levels, but there has been no systematic attempt to identify other such variants. METHODS: We looked for associations between SHBG levels in 1,134 healthy, postmenopausal women and 11 tagging...
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