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Article

Effects of polymorphisms of the sex hormone-binding globulin (SHBG) gene on free estradiol and bone mineral density.

Bone - 1 Dec 2009

Napoli Nicola, Varadharajan Ana, Rini Giovam Batista, Del Fiacco Romano, Yarramaneni Jayasree, Mumm Steven, Villareal Dennis T, Armamento-Villareal Reina

Abstract excerpt

BACKGROUND: Polymorphisms of the sex hormone-binding globulin (SHBG) gene are associated with differences in SHBG levels, influencing the risk for breast cancer and polycystic ovarian syndrome, but no association has been reported for osteoporosis in postmenopausal women. OBJECTIVE: To determine the effect of G to A substitution in the 5'UTR (rs1799941) and the Asp356Asn (rs6259) polymorphisms of the SHBG gene on...

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Source

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Identifiers

PMID: 19679209
DOI: 10.1016/j.bone.2009.08.001
PMCID: PMC3689651

Genes

SHBG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Effects of polymorphisms of the sex hormone-binding globulin (SHBG) gene on free estradiol and bone mineral density.PMID 19679209Read ↗

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