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Associations of sex hormone-binding globulin and testosterone with genome-wide DNA methylation

1 Dec 2018

Abstract excerpt

BACKGROUND: Levels of sex hormone-binding globulin (SHBG) and the androgen testosterone have been associated with risk of diseases throughout the lifecourse. Although both SHBG and testosterone have been shown to be highly heritable, only a fraction of that heritability has been explained by genetic studies. Epigenetic modifications such as DNA methylation may explain some of the missing heritability and could...

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PMID: 30547757
DOI: 10.1186/s12863-018-0703-y

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