Article
Genetic polymorphisms are associated with serum levels of sex hormone binding globulin in postmenopausal women.
BMC medical genetics - 17 Dec 2008
Riancho José A, Valero Carmen, Zarrabeitia María T, García-Unzueta María T, Amado José A, González-Macías Jesús
Abstract excerpt
BACKGROUND: Estrogen activity plays a critical role in bone homeostasis. The serum levels of sex hormone binding globulin (SHBG) influence free estrogen levels and activity on target tissues. The objective of this study was to analyze the influence of common polymorphisms of the SHBG gene on serum SHBG, bone mineral density (BMD), and osteoporotic fractures. METHODS: Four biallelic polymorphisms of the SHBG gene...
Topics
- Aged
- Aged, 80 and over
- Alleles
- Bone Density
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Middle Aged
- Osteoporosis, Postmenopausal
- Polymorphism, Genetic
- Postmenopause
- Sex Hormone-Binding Globulin