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Article

Hepatitis C virus genotype 1b chimeric replicon containing genotype 3 NS5A domain.

Virology - 25 Nov 2006

Lanford Robert E, Guerra Bernadette, Lee Helen

Abstract excerpt

Infections with hepatitis C virus (HCV) genotype 3 exhibit differences in clinical phenotype including an increase in response to interferon therapy and development of steatosis. To initiate studies on genotype 3, we created a chimeric genotype 1b replicon containing a genotype 3a NS5A domain. The chimera was capable of efficient colony formation after the selection of a novel dominant adaptive mutation. Thus,...

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Identifiers

PMID: 16919701
DOI: 10.1016/j.virol.2006.07.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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