Oncogenicity of the ret transforming gene in MMTV/ret transgenic mice.

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Article

Oncogenicity of the ret transforming gene in MMTV/ret transgenic mice.

Oncogene - 1 Apr 1990

Iwamoto T, Takahashi M, Ito M, Hamaguchi M, Isobe K, Misawa N, Asai J, Yoshida T, Nakashima I

Abstract excerpt

We have successfully produced transgenic mice that carry the ret oncogene driven by a mouse mammary tumor virus promoter/enhancer. Mammary and salivary gland adenocarcinomas were developed in a stochastic fashion in these mice. Moreover, premalignant tumors with hyperplastic and dysplastic lesions of Harderian glands and male reproductive tracts frequently occurred at young ages. High expression of the transgene...

Topics

Animals
Blotting, Northern
Cloning, Molecular
Drosophila Proteins
Enhancer Elements, Genetic
Female
Gene Expression Regulation, Viral
Male
Mammary Tumor Virus, Mouse
Mice
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Transgenic

Neoplasms, Experimental

Oncogenes

Pedigree

Phenotype

Phosphotyrosine

Promoter Regions, Genetic

Source

Open in PubMed

Identifiers

PMID: 1691479

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1691479-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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