Article
In wap-ras transgenic mice, tumor phenotype but not cyclophosphamide-sensitivity is affected by genetic background.
Anticancer research - 1 Jan 2000
Nielsen L L, Gurnani M, Catino J J, Tyler R D
Abstract excerpt
Male wap-ras transgenic mice develop adenocarcinomas in salivary and/or mammary tissue by age 1 year. When the wap-ras transgene was bred into the FVB/N strain, males developed multiple mammary tumors between 1.5 and 3 mo. of age, but no salivary tumors. Crosses between ras/FVB mice and other str...
Topics
- Adenocarcinoma
- Animals
- Cyclophosphamide
- Disease Progression
- Female
- Genes, ras
- Male
- Mammary Neoplasms, Experimental
- Mice
- Mice, Inbred C57BL
- Mice, Inbred Strains
- Mice, Mutant Strains
- Mice, Transgenic
- Neoplastic Syndromes, Hereditary
- Phenotype
- Submandibular Gland Neoplasms
- Y Chromosome