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Article

Novel oncogenic actions of TRbeta mutants in tumorigenesis.

IUBMB life - 1 May 2009

Guigon Celine J, Cheng Sheue-yann

Abstract excerpt

The thyroid hormone, T3, plays important roles in metabolism, growth, and differentiation. Germline mutations in thyroid hormone receptor beta (TRbeta) have been identified in many individuals with resistance to thyroid hormone, a syndrome of reduced sensitivity to T3. A close association of somatic mutations of TRbeta with several human cancers has become increasingly apparent, but how TRbeta mutants could be...

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Identifiers

PMID: 19391168
DOI: 10.1002/iub.180
PMCID: PMC2716728

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