Article
Amplification of Ki-ras and elevation of MAP kinase activity during mammary tumor progression in C3(1)/SV40 Tag transgenic mice.
Oncogene - 5 Nov 1998
Liu M L, Von Lintig F C, Liyanage M, Shibata M A, Jorcyk C L, Ried T, Boss G R, Green J E
Abstract excerpt
We have previously documented that transgenic mice expressing SV40 Tag regulated by the rat prostatic steroid-binding protein C3(1) 5'-flanking region display multistage mammary tumorigenesis. To delineate genetic changes associated with mammary tumor progression, comparative genomic hybridizatio...
Topics
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Disease Progression
- Gene Amplification
- Genes, ras
- Guanosine Diphosphate
- Guanosine Triphosphate
- In Situ Hybridization, Fluorescence
- Mammary Neoplasms, Animal
- Mice
- Mice, Transgenic
- Mutation
- RNA, Messenger
- Receptor, ErbB-2
- ras Proteins