Epigenetic mechanisms affect mutant p53 transgene expression in WAP-mutp53 transgenic mice.

doi:10.1038/sj.onc.1208557

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Article

Epigenetic mechanisms affect mutant p53 transgene expression in WAP-mutp53 transgenic mice.

Oncogene - 7 Jul 2005

Krepulat Frauke, Löhler Jürgen, Heinlein Christina, Hermannstädter Andrea, Tolstonog Genrich V, Deppert Wolfgang

Abstract excerpt

We describe the construction and phenotypic characterization of 23 whey acidic protein (WAP)-mutp53 transgenic mouse lines. The mutp53-expressing lines showed a mosaic expression pattern for the transgenes, leading to a heterogeneous yet mouse line-specific expression pattern for mutp53 upon induction. Only few lines were obtained, in which the majority of the induced mammary epithelial cells expressed the mutp53...

Topics

Animals
Cell Line
Disease Models, Animal
Epigenesis, Genetic
Female
Gene Expression Regulation
Genes, p53
Male
Mice
Mice, Transgenic
Milk Proteins
Mosaicism
Mutation
Phenotype
Transgenes

Source

Open in PubMed

Identifiers

PMID: 15870706
DOI: 10.1038/sj.onc.1208557

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