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Article

Epigenetic mechanisms affect mutant p53 transgene expression in WAP-mutp53 transgenic mice.

Oncogene - 7 Jul 2005

Krepulat Frauke, Löhler Jürgen, Heinlein Christina, Hermannstädter Andrea, Tolstonog Genrich V, Deppert Wolfgang

Abstract excerpt

We describe the construction and phenotypic characterization of 23 whey acidic protein (WAP)-mutp53 transgenic mouse lines. The mutp53-expressing lines showed a mosaic expression pattern for the transgenes, leading to a heterogeneous yet mouse line-specific expression pattern for mutp53 upon induction. Only few lines were obtained, in which the majority of the induced mammary epithelial cells expressed the mutp53...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15870706
DOI: 10.1038/sj.onc.1208557

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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