Article
Development of heart valves requires Gata4 expression in endothelial-derived cells.
Development (Cambridge, England) - 1 Sept 2006
Rivera-Feliciano José, Lee Kyu-Ho, Kong Sek Won, Rajagopal Satish, Ma Qing, Springer Zhangli, Izumo Seigo, Tabin Clifford J, Pu William T
Abstract excerpt
Cardiac malformations due to aberrant development of the atrioventricular (AV) valves are among the most common forms of congenital heart disease. At localized swellings of extracellular matrix known as the endocardial cushions, the endothelial lining of the heart undergoes an epithelial to mesenchymal transition (EMT) to form the mesenchymal progenitors of the AV valves. Further growth and differentiation of...
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