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Article

Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa.

Proceedings of the National Academy of Sciences of the United States of America - 27 Apr 2004

Akiyama Haruhiko, Chaboissier Marie-Christine, Behringer Richard R, Rowitch David H, Schedl Andreas, Epstein Jonathan A, de Crombrugghe Benoit

Abstract excerpt

Epithelial-mesenchymal transformation is a critical developmental process reiterated in multiple organs throughout embryogenesis. Formation of endocardial cushions, primordia of valves and septa, is a classic example of epithelial-mesenchymal transformation. Several gene mutations are known to affect cardiac valve formation. Sox9 is activated when endocardial endothelial cells undergo mesenchymal transformation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15096597
DOI: 10.1073/pnas.0401711101
PMCID: PMC404074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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