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Article

SOX9 modulates the expression of key transcription factors required for heart valve development

1 Jan 2015

Abstract excerpt

Heart valve formation initiates when endothelial cells of the heart transform into mesenchyme and populate the cardiac cushions. The transcription factor SOX9 is highly expressed in the cardiac cushion mesenchyme, and is essential for heart valve development. Loss of Sox9 in mouse cardiac cushion mesenchyme alters cell proliferation, embryonic survival, and valve formation. Despite this important role, little is...

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PMID: 26525672
DOI: 10.1242/dev.125252

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