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Article

FRS2α-dependent cell fate transition during endocardial cushion morphogenesis.

Developmental biology - 1 Feb 2020

Chen Dongying, Zhu Xiaolong, Kofler Natalie, Wang Yidong, Zhou Bin, Simons Michael

Abstract excerpt

Atrioventricular valve development requires endothelial-to-mesenchymal transition (EndMT) that induces cushion endocardial cells to give rise to mesenchymal cells crucial to valve formation. In the adult endothelium, deletion of the docking protein FRS2α induces EndMT by activating TGFβ signaling in a miRNA let-7-dependent manner. To study the role of endothelial FRS2α during embryonic development, we generated...

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Identifiers

PMID: 31669335
DOI: 10.1016/j.ydbio.2019.10.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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