Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Yap1 is required for endothelial to mesenchymal transition of the atrioventricular cushion.

The Journal of biological chemistry - 4 Jul 2014

Zhang Hui, von Gise Alexander, Liu Qiaozhen, Hu Tianyuan, Tian Xueying, He Lingjuan, Pu Wenjuan, Huang Xiuzhen, He Liang, Cai Chen-Leng, Camargo Fernando D, Pu William T, Zhou Bin

Abstract excerpt

Cardiac malformations due to aberrant development of the atrioventricular (AV) valves are among the most common forms of congenital heart diseases. Normally, heart valve mesenchyme is formed from an endothelial to mesenchymal transition (EMT) of endothelial cells of the endocardial cushions. Yes-associated protein 1 (YAP1) has been reported to regulate EMT in vitro, in addition to its known role as a major...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transdifferentiation
Share to Endocardium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelial Cells

Share to Mesoderm

Share to Smad Proteins

Share to Snail Family Transcription Factors

Share to Twist-Related Protein 1

Share to YAP-Signaling Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24831012
DOI: 10.1074/jbc.M114.554584
PMCID: PMC4081914

Genes

YAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Yap1 is required for endothelial to mesenchymal transition of the atrioventricular cushion.PMID 24831012Read ↗

Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning.Semantic proximity Read ↗

Mechanisms involved in valvuloseptal endocardial cushion formation in early cardiogenesis: Roles of transforming growth factor (TGF)-β and bone morphogenetic protein (BMP)Semantic proximity Read ↗

The FGF-BMP signaling axis regulates outflow tract valve primordium formation by promoting cushion neural crest cell differentiation.Semantic proximity Read ↗

Development of heart valves requires Gata4 expression in endothelial-derived cells.Semantic proximity Read ↗

Hippo Signaling Mediates TGFβ-Dependent Transcriptional In-Puts in Cardiac Cushion Mesenchymal Cells to Regulate Extracel-Lular Matrix RemodelingSemantic proximity Read ↗

Genetic and cellular analyses of zebrafish atrioventricular cushion and valve developmentSemantic proximity Read ↗

Msx1CreERT2 knock-In allele: A useful tool to target embryonic and adult cardiac valves.Semantic proximity Read ↗

Control of endocardial cushion and cardiac valve maturation by BMP signaling pathways.Semantic proximity Read ↗

Intercalated cushion cells within the cardiac outflow tract are derived from the myocardial troponin T type 2 (Tnnt2) Cre lineageSemantic proximity Read ↗

Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development.Semantic proximity Read ↗

Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formationSemantic proximity Read ↗

Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.