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Article

A critical role for the EphA3 receptor tyrosine kinase in heart development.

Developmental biology - 1 Feb 2007

Stephen Lesley J, Fawkes Amy L, Verhoeve Adam, Lemke Greg, Brown Arthur

Abstract excerpt

Eph proteins are receptor tyrosine kinases that control changes in cell shape and migration during development. We now describe a critical role for EphA3 receptor signaling in heart development as revealed by the phenotype of EphA3 null mice. During heart development mesenchymal outgrowths, the atrioventricular endocardial cushions, form in the atrioventricular canal. This morphogenetic event requires endocardial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Defects, Congenital

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Source

Identifiers

PMID: 17046737
DOI: 10.1016/j.ydbio.2006.08.058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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