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Article

Mutation of keratin 8 in patients with liver disease.

Journal of gastroenterology and hepatology - 1 Sept 2006

Schöniger-Hekele Maximilian, Petermann Dagmar, Müller Christian

Abstract excerpt

BACKGROUND: Epithelial tissues of the gastrointestinal tract and the liver express predominantly cytokeratin 8 and cytokeratin 18. In vitro experiments and animal studies have demonstrated a protective influence of keratin 8 and keratin 18 against toxic damage of hepatocytes. A specific mutation of keratin 8 (G61C) was found to be a genetic risk factor for the development of cryptogenic liver cirrhosis. The...

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Identifiers

PMID: 16911694
DOI: 10.1111/j.1440-1746.2006.04392.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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