Article
Mutation of human keratin 18 in association with cryptogenic cirrhosis.
The Journal of clinical investigation - 1 Jan 1997
Ku N O, Wright T L, Terrault N A, Gish R, Omary M B
Abstract excerpt
Mutations in 11 of the more than 20 keratin intermediate filaments cause several epidermal and oral associated diseases. No disease-associated mutations have been described in keratin 8 or 18 (K8/18) which are the major keratin pair in simple-type epithelia, as found in the liver, pancreas, and intestine. However, transgenic mice that express mutant keratin 18 develop chronic hepatitis, and have an increased...
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