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Article

Keratin variants predispose to acute liver failure and adverse outcome: race and ethnic associations.

Gastroenterology - 1 Sept 2010

Strnad Pavel, Zhou Qin, Hanada Shinichiro, Lazzeroni Laura C, Zhong Bi Hui, So Phillip, Davern Timothy J, Lee William M, Omary M Bishr

Abstract excerpt

BACKGROUND & AIMS: Keratins 8 and 18 (K8/K18) provide anti-apoptotic functions upon liver injury. The cytoprotective function of keratins explains the overrepresentation of K8/K18 variants in patients with cirrhosis. However, K8/K18 variant-associated susceptibility to acute liver injury, which is well-described in animal models, has not been studied in humans. METHODS: We analyzed the entire coding regions of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20538000
DOI: 10.1053/j.gastro.2010.06.007
PMCID: PMC3249217

Genes

KRT18
KRT8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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