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Article

Non-coding keratin variants associate with liver fibrosis progression in patients with hemochromatosis.

PloS one - 1 Jan 2012

Strnad Pavel, Kucukoglu Ozlem, Lunova Mariia, Guldiken Nurdan, Lienau Tim C, Stickel Felix, Omary M Bishr

Abstract excerpt

BACKGROUND: Keratins 8 and 18 (K8/K18) are intermediate filament proteins that protect the liver from various forms of injury. Exonic K8/K18 variants associate with adverse outcome in acute liver failure and with liver fibrosis progression in patients with chronic hepatitis C infection or primary biliary cirrhosis. Given the association of K8/K18 variants with end-stage liver disease and progression in several...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22412904
DOI: 10.1371/journal.pone.0032669
PMCID: PMC3296740

Genes

HFE
KRT8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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