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Article

Prevalence of genetic variants of keratins 8 and 18 in patients with drug-induced liver injury.

BMC medicine - 19 Aug 2015

Usachov Valentyn, Urban Thomas J, Fontana Robert J, Gross Annika, Iyer Sapna, Omary M Bishr, Strnad Pavel

Abstract excerpt

BACKGROUND: Keratin 8 and 18 (K8/K18) cytoskeletal proteins protect hepatocytes from undergoing apoptosis and their mutations predispose to adverse outcomes in acute liver failure (ALF). All known K8/K18 variants occur at relatively non-conserved residues and do not cause keratin cytoskeleton reorganization, whereas epidermal keratin-conserved residue mutations disrupt the keratin cytoskeleton and cause severe...

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Identifiers

PMID: 26286715
DOI: 10.1186/s12916-015-0418-0
PMCID: PMC4545365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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