Article
Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies.
Proceedings of the National Academy of Sciences of the United States of America - 13 May 2003
Ku Nam-On, Darling Jama M, Krams Sheri M, Esquivel Carlos O, Keeffe Emmet B, Sibley Richard K, Lee Young Moo, Wright Teresa L, Omary M Bishr
Abstract excerpt
Keratin 8 and 18 (K8K18) mutations are found in patients with cryptogenic cirrhosis, but the role of keratin mutations in noncryptogenic cirrhosis and the incidence of keratin mutations in the general population are not known. We screened for K8K18 mutations in genomic DNA isolated from 314 liver explants of patients who primarily had noncryptogenic cirrhosis, and from 349 blood bank volunteers. Seven unique...
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