Article
Keratin variants are overrepresented in primary biliary cirrhosis and associate with disease severity.
Hepatology (Baltimore, Md.) - 1 Aug 2009
Zhong Bihui, Strnad Pavel, Selmi Carlo, Invernizzi Pietro, Tao Guo-Zhong, Caleffi Angela, Chen Minhu, Bianchi Ilaria, Podda Mauro, Pietrangelo Antonello, Gershwin M Eric, Omary M Bishr
Abstract excerpt
UNLABELLED: Keratins (K) 8 and 18 variants predispose carriers to the development of end-stage liver disease and patients with chronic hepatitis C to disease progression. Hepatocytes express K8/K18, whereas biliary epithelia express K8/K18/K19. K8-null mice, which are predisposed to liver injury, spontaneously develop anti-mitochondrial antibodies (AMA) and have altered hepatocyte mitochondrial size and function....
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