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Article

Keratin 8 variants are infrequent in patients with alcohol-related liver cirrhosis and do not associate with development of hepatocellular carcinoma.

BMC gastroenterology - 18 Oct 2012

Usachov Valentyn, Nahon Pierre, Lunova Mariia, Ziol Marianne, Rufat Pierre, Sutton Angela, Beaugrand Michel, Strnad Pavel

Abstract excerpt

BACKGROUND: Keratins 8/18 (K8/K18) are established hepatoprotective proteins and K8/K18 variants predispose to development and adverse outcome of multiple liver disorders. The importance of K8/K18 in alcoholic liver disease as well as in established cirrhosis remains unknown. METHODS: We analyzed the K8 mutational hot-spots in 261 prospectively followed-up patients with alcoholic cirrhosis (mean follow-up 65...

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Identifiers

PMID: 23078008
DOI: 10.1186/1471-230X-12-147
PMCID: PMC3527286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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