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Article

ClC-5 does not affect megalin expression and function in the thyroid.

Thyroid : official journal of the American Thyroid Association - 1 Aug 2006

Maritzen Tanja, Lisi Simonetta, Botta Roberta, Pinchera Aldo, Fanelli Giovanni, Viacava Paolo, Marcocci Claudio, Marinò Michele

Abstract excerpt

Megalin is an endocytic receptor responsible for thyroglobulin (Tg) transcytosis, a process that favors hormone release. Accordingly, megalin KO mice have primary hypothyroidism. In the kidney, megalin expression is reduced when the gene encoding the chloride transporter ClC-5 is mutated. We investigated whether megalin expression and function in the thyroid are affected by ClC-5 using a ClC-5 KO mouse model. By...

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Source

Identifiers

PMID: 16910872
DOI: 10.1089/thy.2006.16.725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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