Article
ClC-5: role in endocytosis in the proximal tubule.
American journal of physiology. Renal physiology - 1 Oct 2005
Wang Yinghong, Cai Hui, Cebotaru Liudmila, Hryciw Deanne H, Weinman Edward J, Donowitz Mark, Guggino Sandra E, Guggino William B
Abstract excerpt
The proper functioning of the Cl(-) channel, ClC-5, is essential for the uptake of low molecular mass proteins through receptor-mediated endocytosis in the proximal tubule. Dent's disease patients with mutant ClC-5 channels and ClC-5 knockout (KO) mice both have low molecular mass proteinuria. To further understand the function of ClC-5, endocytosis was studied in LLC-PK(1) cells and primary cultures of proximal...
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