Article
ClC-7 expression levels critically regulate bone turnover, but not gastric acid secretion.
Bone - 1 Jan 2014
Supanchart C, Wartosch L, Schlack C, Kühnisch J, Felsenberg D, Fuhrmann J C, de Vernejoul M-C, Jentsch T J, Kornak U
Abstract excerpt
Mutations in the 2Cl(-)/1H(+)-exchanger ClC-7 impair osteoclast function and cause different types of osteoclast-rich osteopetrosis. However, it is unknown to what extent ClC-7 function has to be reduced to become rate-limiting for bone resorption. In osteoclasts from osteopetrosis patients expression of the mutated ClC-7 protein did not correlate with disease severity and resorption impairment. Therefore, a...
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