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Article

The cytoplasmic domain is not involved in directing Class 5 mutant LDL receptors to lysosomal degradation.

Biochemical and biophysical research communications - 20 May 2011

Strøm Thea Bismo, Tveten Kristian, Holla Øystein L, Cameron Jamie, Berge Knut Erik, Leren Trond P

Abstract excerpt

The low density lipoprotein receptor (LDLR) binds and internalizes low density lipoprotein (LDL). At the mildly acidic pH of the sorting endosomes, LDL is released from the receptor and the receptor recycles back to the cell membrane. Mutations in the LDLR gene may disrupt the normal function of the LDLR in different ways. Class 5 mutations result in receptors that are able to bind and internalize LDL, but they...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21531209
DOI: 10.1016/j.bbrc.2011.04.077

Genes

LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The cytoplasmic domain is not involved in directing Class 5 mutant LDL receptors to lysosomal degradation.PMID 21531209Read ↗

The effect of bafilomycin A1 and protease inhibitors on the degradation and recycling of a Class 5-mutant LDLR.Semantic proximity Read ↗

Intracellular fate of LDL receptor family members depends on the cooperation between their ligand-binding and EGF domains.Semantic proximity Read ↗

Fas ligand is targeted to secretory lysosomes via a proline-rich domain in its cytoplasmic tail.Semantic proximity Read ↗

Mechanism of low density lipoprotein (LDL) release in the endosome: implications of the stability and Ca2+ affinity of the fifth binding module of the LDL receptor.Semantic proximity Read ↗

Fc receptor endocytosis is controlled by a cytoplasmic domain determinant that actively prevents coated pit localization.Semantic proximity Read ↗

Characterization of residues in the cytoplasmic domain of the LDL receptor required for exit from the endoplasmic reticulum.Semantic proximity Read ↗

Deletions in the cytoplasmic domain of the polymeric immunoglobulin receptor differentially affect endocytotic rate and postendocytotic traffic.Semantic proximity Read ↗

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