Article
Role of caveolin-1 in thyroid phenotype, cell homeostasis, and hormone synthesis: in vivo study of caveolin-1 knockout mice.
American journal of physiology. Endocrinology and metabolism - 1 Aug 2009
Senou Maximin, Costa Maria José, Massart Claude, Thimmesch Matthieu, Khalifa Céline, Poncin Sylvie, Boucquey Marie, Gérard Anne-Catherine, Audinot Jean-Nicolas, Dessy Chantal, Ruf Jean, Feron Olivier, Devuyst Olivier, Guiot Yves, Dumont Jacques Emile, Van Sande Jacqueline, Many Marie-Christine
Abstract excerpt
In human thyroid, caveolin-1 is localized at the apex of thyrocytes, but its role there remains unknown. Using immunohistochemistry, (127)I imaging, transmission electron microscopy, immunogold electron microscopy, and quantification of H(2)O(2), we found that in caveolin-1 knockout mice thyroid cell homeostasis was disrupted, with evidence of oxidative stress, cell damage, and apoptosis. An even more striking...
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