Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diet-dependent hypercalciuria in transgenic mice with reduced CLC5 chloride channel expression.

Proceedings of the National Academy of Sciences of the United States of America - 12 Oct 1999

Luyckx V A, Leclercq B, Dowland L K, Yu A S

Abstract excerpt

Dent's disease is an X-linked inherited disorder characterized by hypercalciuria, nephrocalcinosis, nephrolithiasis, low molecular weight proteinuria, Fanconi's syndrome, and renal failure. It is caused by inactivating mutations in CLC5, a member of the CLC voltage-gated chloride channel family. CLC5 is known to be expressed in the endosomal compartment of the renal proximal tubule, where it may be required for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Weight
Share to Calcium
Share to Chloride Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrolytes

Share to Kidney

Share to RNA, Catalytic

Share to Sequence Homology, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 10518595
DOI: 10.1073/pnas.96.21.12174
PMCID: PMC18431

Genes

CLC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diet-dependent hypercalciuria in transgenic mice with reduced CLC5 chloride channel expression.PMID 10518595Read ↗

Bone marrow transplantation improves proximal tubule dysfunction in a mouse model of Dent disease.Semantic proximity Read ↗

Characterization of renal chloride channel (CLCN5) mutations in Dent's disease.Semantic proximity Read ↗

4-Phenylbutyric Acid Treatment Reduces Low-Molecular-Weight Proteinuria in a Clcn5 Knock-in Mouse Model for Dent Disease-1.Semantic proximity Read ↗

ClC transporters: discoveries and challenges in defining the mechanisms underlying function and regulation of ClC-5.Semantic proximity Read ↗

Global gene-expression analysis reveals the molecular processes underlying ClC-5 loss-of-function in novel Dent Disease 1 cellular modelsSemantic proximity Read ↗

Can we generate new hypotheses about Dent's disease from gene analysis of a mouse model?Semantic proximity Read ↗

ClC-5 chloride channel and kidney stones: what is the link?Semantic proximity Read ↗

Inherited hypercalciuric syndromes: Dent's disease (CLC-5) and familial hypomagnesemia with hypercalciuria (paracellin-1).Semantic proximity Read ↗

A novel CLCN5 pathogenic mutation supports Dent disease with normal endosomal acidification.Semantic proximity Read ↗

Examination of megalin in renal tubular epithelium from patients with Dent disease.Semantic proximity Read ↗

Kidney Tubular Ablation of Ocrl/Inpp5b Phenocopies Lowe Syndrome Tubulopathy.Semantic proximity Read ↗

Novel Dent disease 1 cellular models reveal biological processes underlying ClC-5 loss-of-function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.